New Amsterdam 5x12
Download === https://bytlly.com/2tl99T
From a molecular perspective on sarcopenia as a key trigger ofstrength declines during aging, Heisterberg and colleagues [OP-PM10] statedthat satellite cells are important for the plasticity and regenerativecapacity of the skeletal muscle. An aging-induced decline of satellite-cellfunction seems to be linked with an increased TGF-beta signaling. Thismechanism was previously identified by Carlson et al. (EMBO MolecularMedicine, 2009). Blocking angiotensin II (by means of Losartan) in sarcopenicmice down-regulates TGF-beta and IGF-1 that might enhance muscle adaptationfollowing exercise training. Twenty-six elderly men (64+ years of age)performed one bout of heavy one-legged resistance exercises comprising 5x12repetitions of concentric work (70% of 1RM) and 4x6 repetitions of eccentricwork (110% of 1RM). The authors did not find any effect of Losartan on themuscle response to acute exercise. The authors, however, stated that longertreatments and exercise periods might yield larger effects. 59ce067264